THE PRIME MINISTER – Matteo Renzi is out to change Italy, perhaps more than any other politician in memory. With the referendum on his radical idea to eliminate hundreds of elected officials coming up next week, he tells Charlie Rose why he wants to do it. Draggan Mihailovich is the producer.

THE ALZHEIMER’S LABORATORY – Scientists are hoping volunteers from the world’s largest concentration of people with a rare genetic mutation that causes early-onset Alzheimer’s may help prevent the disease in others someday. Lesley Stahl goes to Medellin, Colombia. Shari Finkelstein is the producer. This is a double length segment.

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